![]() Though there's an inherent risk when you get behind the wheel, these driving safety tips should help Florida teens stay safe then they're on the road. Upon passing a 30 question written test you will be issued an instruction permit. It recommends maintaining a distance of at least four seconds behind the car in front of you. Your name on your drivers license and social security card must match. The Florida Driver License Handbook says that most rear-end collisions are caused by drivers who followed too closely. While you're driving, be sure not to exceed the speed limit and leave plenty of space between yourself and the car in front of you. Google Maps is a great tool for checking traffic before you leave the house (but don't check it when you're on the road). For this reason, Florida teens should always give themselves plenty of time to get where they're going. If you're rushing to get somewhere, you're more likely to drive recklessly. No one likes being late, but it's certainly a better alternative to being in a car accident. Drivers who got between four and five hours of sleep are four times as likely to get into a crash, and those who slept fewer than four hours are a whopping 12 times as likely to be in a wreck. According to a study released by the American Automobile Association (AAA) last year, drivers who got five or six hours of sleep the night before are twice as likely to be involved in a collision as those who got a full night's sleep. It's also tough to focus on the road when you're tired. While driving, however, Florida teens should avoid using their phones or any other electronic devices. In this day and age, we're used to being connected. ![]() Avoiding distractions is one of the best driving safety tips there is. Though it's legal to talk on a hand-held phone while driving in the state of Florida, it's best to go off-the-grid while you're behind the wheel. The CDC says that seat belts reduce serious accident-related injuries and fatalities by about 50 percent. Not only can buckling up save you from an expensive ticket, but it can also save your life. Florida law requires all passengers to wear their seat belts at all times. The importance of wearing your seat belt might seem obvious, but more than 26,000 Florida teens were cited for seat belt violations in 2014 alone. For this reason, Florida teens should be sure to follow these driving safety tips. ![]() According to the Center for Disease Control (CDC), 16- to 19-year-olds are more likely to be involved in motor vehicle crashes than any other group. Though driver education courses can do a great job preparing you for the open road, you can never be too careful when it comes to driving. Getting your driver license is a big milestone, but it's also a big responsibility.
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(H) The fluorescent intensity per micrometer of peribronchial collagen type I in 10 random basement membrane fields in G and presented as the mean ± SEM, * p<0.01. (G) Immunohistochemistry of collagen type I (Col I) in the lungs of WT and Lyn −/− mice exposed to dust mite or PBS. (F) Quantification of PAS positive cells percentage in 10 random airway epithelial cells fields in E (original magnification, ×200, * p<0.01). (E) PAS staining of epithelial goblet cells in the lungs of WT and Lyn −/− mice exposed to dust mite or PBS. (D) MUC5AC protein was also determined in Lyn −/− mice and WT mice using ELISPOT assay. GAPDH was measured for internal controls. (C) MUC5AC mRNA expression was determined in the lungs of Lyn −/− mice and WT mice using RT-PCR. Positive cells were counted in 10 random airway epithelial cells fields and presented as the mean ± SEM. ( B) Percentages of cells staining positive for MUC5AC in A. Arrow shows MUC5AC positive cells in airway in A (the markers similarly indicated below). (A) Immunohistochemistry of MUC5AC in the lungs of WT and Lyn −/− mice exposed to dust mite or PBS (merged images). Collectively, these findings revealed that Lyn regulates TGF-β3 isoform and modulates the development of airway remodeling, which may have therapeutic implications for severe chronic asthma. ![]() ![]() Finally, Lyn may critically regulate airway remodeling by directly interacting with TGF-β3. Further examination of chronic asthma patients showed that a decreased Lyn correlated with the severity of airway inflammation and mucus hypersecretion. In addition, both recombinant and adenoviral TGF-β3 significantly promoted epithelial-to-mesenchymal transition and intensified collagen I production and MUC5AC expression. Furthermore, TGF-β3 neutralizing Abs not only inhibited the expression of STAT6 and Smad2/3 but also decreased phosphorylation of Smad2 and NF-κB in Lyn(-/-) mouse lungs. 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